G-Protein Types Involved in Calcium Channel Inhibition at a Presynaptic Nerve Terminal
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چکیده
منابع مشابه
G-Protein types involved in calcium channel inhibition at a presynaptic nerve terminal.
The inhibition of presynaptic calcium channels via G-protein-dependent second messenger pathways is a key mechanism of transmitter release modulation. We used the calyx-type nerve terminal of the chick ciliary ganglion to examine which G-proteins are involved in the voltage-sensitive inhibition of presynaptic N-type calcium channels. Adenosine caused a prominent inhibition of the calcium curren...
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Calcium currents were recorded from a cholinergic presynaptic nerve terminal in the chick ciliary ganglion using the whole-cell voltage-clamp technique. The presynaptic element of this synapse is in the form of a calyx that envelops the postsynaptic ciliary neuron. A method was developed to isolate the ciliary neuron, expose the calyx, and apply patch-clamp electrodes under visual control. The ...
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Release of chemical messengers from synaptic vesicles is the result of a highly orchestrated process of membrane trafficking in the presynaptic nerve terminal. Understanding the molecular mechanisms that govern synaptic vesicle membrane trafficking is of inherent interest to cell biologists; however, an additional fascination arises from the notion that the modulation of neurotransmitter releas...
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ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 2000
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.20-20-07614.2000